Reigning champion Real (22-3) will look to seal playoff qualification by overcoming a Milan team (10-15) desperate to push closer to the top 10.
Ettore Messina, Milan: 'We intend to compete with great respect'

Fit-again Nikola Mirotic will try to punish his former club in what promises to be a bruising head-to-head battle with Guerschon Yabusele. Real had no trouble in claiming a comfortable win, 88-71, when the teams met in Round 4, led by 19 points on 5 three-pointers from Sergio Llull. The Italian team has slipped down the standings by winning just one of its last five games and has lost four straight on the road, while Real is the only team in the competition with a perfect home record.
Ettore Messina, Milan head coach
"We face the defending champions, and we intend to compete with great respect and humbleness for what they are and represent. At the same time we firmly want to improve the quality of our game for the entire 40 minutes and we will give our best to try to win a very prestigious game."
Chus Mateo, Real Madrid head coach
"I expect a concentrated Milan team that wants to keep doing things the right way. They are on their way to finish the regular season in important positions and they will keep competing in all EuroLeague games. They are fighting for the play-in and they want to send a message. That's why I expect a hungry opponent in this game. Winning on the road is very hard in this league and I hope we play focused and that we follow the compass."
Sergio Rodriguez, Real Madrid player
"We will be facing a team that needs wins. They are talented and they got some players back from injury plus a great coach. This is the last EuroLeague game before the break, and we want to keep winning. We go there with ambition, but it will be difficult to win in Milan because the arena will be packed and we are facing a team that is used to winning in important games. We will have to limit their virtues in order to win."